The influence of different sources of polyphenols on submaximal cycling and time trial performance

The primary purpose of the study was to establish the effects of commercially available polyphenol-rich antioxidant supplements, Pycnogenol® with added bioflavonoids (PYC-B) and CherryActive (CHA), on 20 km cycling performance. Using a double-blind counterbalanced, repeated-measures design, nine male cyclists or triathletes (32.1 ± 11.2 years; maximal aerobic capacity 4.2 ± 0.7 L•min-1; maximal power output 391.7 ± 39.5 watts) consumed 200 mg of CHA, 120 mg of PYC-B, or 200 mg of placebo (PLA) capsules, 2 days before and on the day of each experimental trial. The experimental trials consisted of four 5 minute stages at 40%, 50%, 60%, and 70% maximal power output (Wmax), followed by a 20 km time trial (TT). Statistical analysis revealed no significant differences between trials for heart rate, respiratory exchange ratio, gross mechanical efficiency, oxygen consumption, or blood lactate, at any of the intensities completed during the initial 20 minute phase of the trial (p>0.05). Final 20 km TT times were not significantly different between trials (p=0.115), but, compared to PLA, PYC-B did significantly increase power output by 6.2% over the final 5 km of the TT (p=0.022). The study suggests that the PYC-B supplement could be beneficial towards the end of an intense bout of cycling exercise. However, as total 20 km time was not significantly different between trials the doses used are unlikely to benefit 20 km cycling time trial performance

Quality of schooling and inequality of opportunity in health

This paper explores the role of quality of schooling as a source of inequality of opportunity in health. Substantiating earlier literature that links differences in education to health disparities, the paper uses variation in quality of schooling to test for inequality of opportunity in health. Analysis of the 1958 NCDS cohort exploits the variation in type and quality of schools generated by the comprehensive schooling reforms in England and Wales. The analysis provides evidence of a statistically significant and economically sizable association between some dimensions of quality of education and a range of health and health-related outcomes. For some outcomes the association persists, over and above the effects of measured ability, social development, academic qualifications and adult socioeconomic status and lifestyle

Long-term effects of school quality on health and lifestyle: evidence from comprehensive schooling reforms in England

Members of the National Child Development Study cohort attended very different types of secondary schools, as their schooling lay within the transition period of the comprehensive education reform in England and Wales. This provides a natural setting to explore the impact of educational attainment and of school quality on health and health-related behavior later in life. We use a combination of matching methods and parametric regressions to deal with selection effects and to evaluate differences in adult health outcomes and health-related behavior for cohort members exposed to the old selective and to the new comprehensive educational systems

Assessment of Coating Performance on Waterwalls and Superheaters in a Pulverised Fuel-Fired Power Station

Protective coatings offer one route to increase the lives of heat exchangers in pulverised fuel power plants. A range of candidate coatings have been exposed on the waterwall and superheaters of a 500 MWe UK power station unit for periods of up to ~4 years (24,880 operating hours), during which time this unit was fired on a mixture of UK and world-traded coals. Both nickel- and iron-based candidate coatings were included, applied using high velocity oxy-fuel or arc-wire process; a selection of these also had a surface sealant applied to investigate its effectiveness. Dimensional metrology was used to evaluate coating performances, with SEM/EDX examinations used to investigate the various degradation mechanisms found. Both the waterwall and superheater environments generated their characteristic corrosion damage morphologies which depended on the radial positions around the tube. Coating performances were found to depend on the initial coating quality rather than composition, and were not improved by the use of a sealant

The use of field-programmable gate arrays for the hardware acceleration of design automation tasks

This paper investigates the possibility of using Field-Programmable Gate Arrays (Fr’GAS) as reconfigurable co-processors for workstations to produce moderate speedups for most tasks in the design process, resulting in a worthwhile overall design process speedup at low cost and allowing algorithm upgrades with no hardware modification. The use of FPGAS as hardware accelerators is reviewed and then achievable speedups are predicted for logic simulation and VLSI design rule checking tasks for various FPGA co-processor arrangements

Simulation-based Inference in Dynamic Panel Probit Models: an Application to Health

This paper considers the determinants of a binary indicator for the existence of functional limitations using seven waves (1991-1997) of the British Household Panel Survey(BHPS). The focal point of our analysis is a consideration of the relative contributions of state dependence, heterogeneity and serial correlation in expanding the dynamics of health. To investigate these issues we apply static and dynamic panel probit models with flexible error structures. To estimate the models we show strong positive state dependence, with the effect for men around 150% of the effect for women.

Early Retirement and Inequality in Britain and Germany: How Important Is Health?

Both health and income inequalities have been shown to be much greater in Britain than in Germany. One of the main reasons seems to be the difference in the relative position of the retired, who, in Britain, are much more concentrated in the lower income groups. Inequality analysis reveals that while the distribution of health shocks is more concentrated among those on low incomes in Britain, early retirement is more concentrated among those on high incomes. In contrast, in Germany, both health shocks and early retirement are more concentrated among those with low incomes. We use comparable longitudinal data sets from Britain and Germany to estimate hazard models of the effect of health on early retirement. The hazard models show that health is a key determinant of the retirement hazard for both men and women in Britain and Germany. The size of the health effect appears large compared to the other variables. Designing financial incentives to encourage people to work for longer may not be sufficient as a policy tool if people are leaving the labour market involuntarily due to health problems.health, early retirement, hazard models

Towards adaptive operational requirements for optimal application of evaporation-suppressing monolayer to reservoirs via a 'universal design framework'

Much of the chemical monolayer-based evaporation mitigation research was generated in the 1950s, 60s and 70s centred on the use of spreading long-chain fatty alcohols, such as hexadecanol (C16) and octadecanol (C18), on the water surface. Many researchers from this era have reported highly variable performance results (anywhere from 0-30% efficiency) attributing the highly variable evaporation reduction achieved to film volatilisation, drift, beaching on the lee shore and waves which can break-up or submerge the film.Failure to address this requirement has undoubtedly contributed to the lack of development in the use of monolayers despite some demonstration of useful evaporation suppression performance. In addition recent studies have also indicated that all water bodies have a naturally-occurring surface film, referred to as a microlayer, which can interact with artificial (chemical) monolayers. Natural microlayers are produced by hydrophobic plant waxes, phenolic compounds and other humified material, which concentrates populations of micro-organisms capable of utilizing these materials as organic substrates. This explains why common artificial monolayers (with carbon chain lengths of up to 16) are highly susceptible to biodegradation. Studies on Australian brown water storages reveal highly concentrated microbial microlayer communities, due to the coincidence of leaf and bark fall with low rainfall (Pittaway and van den Ancker 2009). This variation in the concentration of humified organic compounds in the storages is associated with both the volume of the storage, and the riparian vegetation within the water catchment. This paper sets out a strategic approach to the use of monolayer on a reservoir for evaporation mitigation. The approach recognises that every reservoir will have a specific set of user and environmental considerations which leads to a unique set of operational requirements. In order to capture and utilise this information a Universal Design Framework (UDF) has been developed. The UDF serves two purposes, firstly to inform the selection of monolayer material and system design for any given site (‘Planning Mode’), and secondly to inform (and potentially autonomously manage) day-to-day operations, i.e. the timing and amounts of monolayer application (‘Operational Mode’). The UDF takes into account the following parameters: • Critical water requirement periods: These will vary from location to location and at different times of the year. Hence, this is a user determined input. • Economics: The dollars-per-megalitre value of water will also vary from location to location and at different time of the year with respect to critical water requirement periods (e.g. irrigated cropping close to harvest). Included in this input is a user defined annual maximum cost outlay for the monolayer-based system. • Water storage factors: Inputs differ slightly depending on storage type (i.e. ring tank versus gully dam), but generally require information of length, width, shape, bank height, freeboard, full supply volume and geographical co-ordinate points for storage orientation. This would be determined by a basic on-site analysis • Climate and weather factors: Monthly average evaporation demand, rainfall and ambient air temperature information is required, including particularly wind speed frequency and prevailing wind direction, (e.g. from a local Automatic Weather Station (AWS) or via the Bureau of Meteorology SILO database, http://www.longpaddock.qld.gov.au/silo/). In the Planning Mode mean and extreme historical climate data are used; and in the Operational Mode prevailing conditions are required. • Water quality and biological factors: Assessments are made of water source/s (e.g. runoff versus bore), water colour, turbidity, water chemistry (pH, electrical conductivity and UV absorbency), plus density of local catchment vegetation and catchment area. Once the above parameters are known, the UDF is used to determine (in Planning Mode) the most suitable monolayer material/s and optimal arrangement of application equipment, including number of applicators, their arrangement and application strategies for the particular reservoir and monolayer product. In Operational Mode the UDF will guide (or if required, fully control) operational procedures, i.e. the implementation of a unique application strategy for a specific product according to the hour-by-hour prevailing conditions. This paper also outlines decision-making processes within the UDF. Firstly, to determine suitable monolayer materials the UDF compares water quality and biological characteristics of the particular site to those of six benchmark reservoirs in SE Queensland which have been studied in detail (Pittaway and van den Ancker 2009). The biologically-closest informs the choice of appropriate monolayer material/s. Once the selection of a monolayer is made there are a number of unique characteristics that material possesses that will substantially influence the application strategies. Secondly, a simulation platform has been developed to determine the application strategies and operational requirements for the reservoir. The simulation enables rapid evaluation of a range of different sample water bodies to populate a decision chart similar to that for monolayer material selection. A central component of the simulation platform is a fluid-mechanical model of the dispersal of monolayer across a water surface area under the influence of environmental variables, principally wind speed and wind direction, which (in Planning Mode) determines: • optimal spacing between application points, • amount of monolayer applied from each applicator as well as the total amount applied, • placement of applicators to achieve optimal surface coverage, • number of applicator types required, and • percentage of surface coverage under a range of wind speeds and directions. The above simulated output information is unique to the particular reservoir and is essentially a specification for the design and operation of a monolayer application system for that specific site, and is used firstly (Planning Mode) to select appropriate application equipment capable of satisfying the monolayer application requirements; and secondly, if installed as planned, as the basis for day-to-day monolayer application (Operational Mode). Simulation results to date indicate that from large reservoirs, optimal surface coverage is best achieved by a number of fixed application points surrounding and within the reservoir spaced no further than 12 metres apart; and that a greater concentration of applicators is required upwind from the prevailing wind direction in addition to higher rates of monolayer application

Developing concepts of musical style

This thesis explores the development of sensitivity to musical styles in children aged between 3 and 16 years old. The thesis is divided into four parts. The first part of the thesis explores the historical background of the developmental and the social psychology of music and reviews some pertinent previous literature. This section places the later studies in a theoretical context. The second part presents a review of the four previous studies, which have been carried out into style sensitivity, namely, Gardner (1973), Castell (1983), Tafuri et al. (1994) and Hargreaves and North (1999). This section of the thesis also includes a review of a number of methodological issues and gives a full description of the design of the test methodology. Six experiments are carried out and reported in the thesis. Experiment one explores the effect of varying the lesson context in which the style sensitivity test is presented to the participants, whilst experiment two explores the effect of varying the test presenter on participants' test performance. The third experiment is a comparative study between participants in three different regions, one region within the UK and two regions within the USA. The participants in each of these three regions all experienced a number of variations in their music education programme, the status accorded to music within that music education programme and also considerable variation in participants' commercial musical diet. The experiment explores whether or not these variations affect the development of sensitivity to musical styles. Part three of the thesis manipulates two further variables firstly, by varying the introduction to the style sensitivity and secondly, by manipulating the musical material used in the test. Experiment four presents two variations to the test introduction. In the first condition the introduction is changed through the offer of a reward and in the second condition, the introduction is changed in order to make the experiment competitive. The fifth experiment attempts to manipulate the musical material used in the style sensitivity test by increasing the level of stylistic divergence between the musical extracts. This is achieved in two ways. Firstly, a broad grained method of measuring various artefactual elements within the extracts is devised and incorporated into the selection of the musical test material. Secondly, the stylistic divergence between the musical extracts in increased by extending the chronological period between the musical eras used in the musical extracts. Part four presents the findings of an exploratory study. Experiment six attempted to create a new test methodology which was appropriate for use on younger children. The new methodology was successfully piloted in order to further explore style sensitivity in participants aged between 3 and 5 years of age. In the last section, a review of the six experiments is given and this is accompanied by a number of implications for further research. Finally, a model of the development of style sensitivity is presented. This model proposes that sensitivity to musical style is not a single unitary skill, the development of which is linear, and therefore any measurement of musical style sensitivity should be seen as a multidimensional description of a combination of abilities, skills and knowledge. The model proposes that acquiring the ability to be sensitive to musical styles can best be seen as the progression from stylistic discrimination to stylistic competence

Structural Investigations of Creatine Kinase

X-ray crystallographic and other structural studies have been carried out on creatine kinase isolated from rabbit skeletal muscle. As a consequence of the exploration of a wide range of crystallisation conditions, a previously unreported crystal form of creatine kinase has been characterised. This crystal form is monoclinic C2 with three subunits in the asymmetric unit and cell dimensions a = 248 A, b = 149 A, c = 52 A, beta = 9